Abstract
Fatty acid amide hydrolase (FAAH) is the major catabolic enzyme for the endocannabinoid anandamide. A common functional single nucleotide polymorphism (rs324420, 385C/A) in FAAH has been linked with decreased self-reported anxiety during stress exposure and decreased amygdala responses to facial cues signaling threat. The goal of the current study was to test the hypothesis that FAAH levels measured in vivo in brain would correlate with amygdala reactivity to pictures of angry facial expressions.
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