Abstract
Fatty acid amide hydrolase (FAAH) is the major enzyme for the endocannabinoid anandamide. A functional single nucleotide polymorphism (SNP) (C385A) in the gene for FAAH has been linked with decreased self-reported anxiety during stress exposure and decreased amygdala reactivity to facial cues signaling threat. Further, our group recently reported a relationship between FAAH levels in brain measured with Positron Emission Tomography (PET) imaging and functional connectivity in amygdala-related circuits.
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