Abstract
ObjectivesTo study the clinic-pathological characteristics of malignant neoplasms of the salivary glands (MNSG) and determine their importance in disease progression. Material and methodsWe conducted a descriptive study of 136 patients with MNSG diagnosed between 1992 and 2002 in the Instituto Português de Oncologia do Porto. Through of the review of the clinical records we studied several clinical and pathological variables. The overall and disease-free survival were analyzed by Kaplan-Meier method and log-rank test. For multivariate analysis we used Cox regression method. ResultsOf 136 cases of MNSG, 75 (55.1%) were male and 61 (44.9%) were female, (median age of 57.5 years). The most frequent histological type was adenoid cystic carcinoma (n=34), followed by mucoepidermoid carcinoma (n=29). Regarding location, 89 (65.4%) neoplasms affected major salivary glands and 47 (34.6%) minor salivary glands. The overall and disease-free survivals at 60 months were 71%. The variables independently associated with overall survival were the stage (p<0.0001) and malignancy grade (p=0.03). The presence of local invasion (p<0.0001) and the malignancy grade (p=0.04) were associated with worse disease-free survival in multivariate analysis. ConclusionMNSG are a heterogeneous group most represented by adenoid cystic carcinoma and mucoepidermoid carcinomas. Stage and the malignancy grade remain as key prognostic factors to take into account comparing with the majority of clinical and pathological variables, contributing to the stratification of patients for treatment and prognosis.
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