Abstract
In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
