Abstract

New neurons are generated throughout life. This discovery has challenged firmly held concepts about the structural plasticity and regenerative capacity of the mammalian brain. In this special issue of the EJN, leaders in the field summarize and review recent advances aiming to understand the molecular mechanisms underlying adult neurogenesis and the impact of new neurons on brain function in health and disease. Below we discuss pivotal yet unsolved aspects of adult neurogenesis as well as potential future directions in the field.

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