Abstract
Cholesteryl ester hydroperoxide (CE-OOH) and phosphatidylcholine hydroperoxide (PC-OOH) are the major primary oxidation products of lipoproteins. CE-OOH is present in human and rat plasmas while PC-OOH is undetectable. This is likely due to the enzymatic (plasma glutathione peroxidase) and the nonenzymatic (apolipoproteins A and B-100) reducing activities of PC-OOH in plasma, and to the enzymatic conversion of PC-OOH to CE-OOH by lecithin:cholesterol acyltransferase in high density lipoproteins. The regioisomeric distribution of CE-O(O)H in human plasma indicates that free radical-mediated chain oxidation is an ongoing process, even in healthy young individuals.
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