Fatal Adenovirus Pneumonia in a Young Adult Associated with ADV-7 Vaccine Administered 15 Days Earlier

Abstract

A 19-year-old man presented with mild respiratory distress and bilateral interstitial infiltrates on chest roentgenogram. Progressive, ultimately fatal, respiratory failure ensued. Although he had received adenovirus (ADV) 4 and 7 oral vaccine, the etiology was most likely ADV-7. To our knowledge, this is the first reported case of fulminant ADV-7 pneumonitis associated with prior administration of ADV-7 vaccine.