Fat Restriction Is Associated with Impaired Quality of Life in Patients with Ulcerative Colitis and Crohn's Disease

A Kuwabara,K Tanaka,N Inagaki,H Nakase,K Shide,T Chiba,H Tsuji

doi:10.1155/2011/594532

A Kuwabara, K Tanaka + Show 5 more

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https://doi.org/10.1155/2011/594532

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Abstract

Inflammatory bowel disease (IBD), ulcerative colitis (UC) and Crohn's disease, is reported to be associated with impaired health-related quality of life (QOL). Although decreased QOL in these subjects has been reported to be associated with various factors, the effect of nutritional therapy, especially nutrients intake on QOL has received less attention. In this study, we evaluated the various factors including nutrients intake on QOL using SF-8 in 64 patients with IBD. Patients with IBD seem to have decreased QOL especially in the mental aspects. The percentage energy intake from fat of total energy fat intake (% energy) of the whole subjects, was lower than those of the annual National Nutrition Survey in Japan. Multiple regression analyses revealed that fat intake (% energy) was a significant predictor for mental component summary. In conclusion, fat restriction contributes to impaired QOL especially in the mental aspects in IBD patients.

Highlights

Inflammatory bowel disease (IBD); ulcerative colitis (UC) and Crohn’s disease, is reported to be associated with impaired health-related quality of life (HR-QOL)
By their definition, only consist of questions related to the subjects’ general status and do not include the questions related to the features which are specific to a certain disease
They are applicable to such studies as comparing the impact on QOL by various diseases or even to the evaluation of healthy subjects

Summary

Introduction

Inflammatory bowel disease (IBD); ulcerative colitis (UC) and Crohn’s disease, is reported to be associated with impaired health-related quality of life (HR-QOL). Decreased QOL in these subjects has been reported to be related to various factors such as age, gender [1, 2], treatment effects [3], disease activity, and social environment [4]. Plasma concentrations of vitamin D and K were correlated with the fat intake but not with their intake of these vitamins. These results were more prominent in patients with CD than those with UC. It was concluded that fat-soluble substances such as vitamin D and K were not effectively absorbed from the intestine without concomitant intake of enough fat

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