Abstract
Fasting regulates FSP27 expression in the liver
Highlights
FSP27 is a lipid droplet (LD) associated protein that is transcriptionally regulated by peroxisome proliferatoractivated receptor (PPAR)␥ during differentiation in adipocytes [1,2,3]
It was confirmed that hepatic steatosis in leptin-deficient mice is promoted by FSP27 [15]
It is clearly established that FSP27 plays an important role in hepatic steatosis in mouse models by promoting PPAR␥-mediated hepatic steatosis [7, 15]
Summary
FSP27 is a lipid droplet (LD) associated protein that is transcriptionally regulated by peroxisome proliferatoractivated receptor (PPAR)␥ during differentiation in adipocytes [1,2,3]. The very first report on the regulation of FSP27 in liver was from Reddy’s laboratory in which Yu et al elegantly showed that PPAR␥ overexpression in the liver of PPAR␣(−/−) mice induced FSP27 among other lipogenesisrelated genes [7]. Forced expression of FSP27 in hepatocytes in vitro or in vivo leads to increased LD formation through increased triglyceride levels, whereas repressed FSP27 inhibits hepatic lipid accumulation in both db/db and high-fat diet-fed mice lacking mitogen-activated protein phosphatase-1 (MKP-1) [16].
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