Abstract
Repair effect on TMP radical anions by phenylpropanoid glycosides (PPGs) and their analogs, isolated from Chinese folk medicinal herbs, were studied using a pulse radiolysis technique. The radical anion of TMP was formed by the reaction of hydrated electron with TMP. On pulse irradiation of a nitrogen saturated TMP aqueous solution containing 0.2 mol/l t-BuOH and one of the PPGs or their analogs, the transient absorption spectrum of the radical anion of TMP decayed with the formation of that of the radical anion of PPGs or their analogs within several decades of microseconds after electron pulse irradiation. The results indicated that TMP radical anions can be repaired by PPGs or their analogs. The rate constants of the repair reactions were deduced to be 1.64–2.75×10 9 M −1 s −1. A deeper understanding of this new repair mechanism will undoubtedly help researchers design strategies to prevent and/or intervene more effectively in free radical related diseases.
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