Abstract
Fast, heart-rate independent, whole-heart, free-breathing, three-dimensional myocardial BOLD MRI at 3T with simultaneous 13N-ammonia PET validation in canines
Highlights
Myocardial BOLD MRI is a non-contrast approach for examining myocardial perfusion
We tested our method in a canine model and validated our findings with simultaneously acquired 13N-ammonia PET perfusion data in a whole-body PET/MR system
Qavg were significantly higher during adenosine stress relative to rest (Qavg: 0.8 ± 0.1 ml/mg/min vs 2.0 ± 0.9 ml/mg/min; p < 0.05)
Summary
Myocardial BOLD MRI is a non-contrast approach for examining myocardial perfusion. Recent developments have shown promising technical advancements, current myocardial BOLD MR methods are still limited by: (a) poor spatial coverage; (b) imaging confounders; and (c) imaging artifacts, at 3T. To address these limitations, we developed a heart-rate independent, free-breathing 3D T2 mapping technique at 3T that utilizes near 100% imaging efficiency, which can be completed within 3 minutes. We tested our method in a canine model and validated our findings with simultaneously acquired 13N-ammonia PET perfusion data in a whole-body PET/MR system
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