Abstract
Background Myocardial BOLD MRI is an emerging non-contrast approach for the assessment of ischemic heart disease. However, current BOLD CMR methods (T2-weighted, T2*-weighted or bSSFP) are limited by poor spatial coverage and image artifacts (e.g. coil bias, B1 and B0 inhomogeneities). To address these limitations, we developed a fast, free breathing 3D T2 mapping technique at 3T that utilizes near 100% imaging efficiency. This quantitative BOLD approach, which can be performed within 5 minutes, permits full LV coverage during adenosine stress. In this study, we tested our approach in a canine model and validated our findings with simultaneously acquired 13 Nammonia PET perfusion data in a clinical PET-MR system.
Highlights
Myocardial BOLD MRI is an emerging non-contrast approach for the assessment of ischemic heart disease
We developed a fast, free breathing 3D T2 mapping technique at 3T that utilizes near 100% imaging efficiency
After scouting and whole-heart shimming, fast 3D free-breathing T2 mapping sequence were prescribed at rest and under adenosine stress (140 mg/min/kg) with the following scan parameters: TR/TE =3.4/1.7 ms, flip angle = 15°, imaging resolution = 2 x 2 x 6 mm3 with 14 partitions, adiabatic T2 prep pulses every other heart beat
Summary
Whole-heart, free-breathing, three-dimensional myocardial BOLD MRI at 3T with simultaneous 13N-ammonia PET in canines. Hsin-Jung Yang1*, Damini Dey, Jane Sykes, John Butler, Avinash Kali, Ivan Cokic, Behzad Sharif, Debiao Li1, Sotirios Tsaftaris, Piotr Slomka, Frank S Prato, Rohan Dharmakumar
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