Fast detection of tumor marker CA 19-9 using AlGaN/GaN high electron mobility transistors

Abstract

Early detection of cancerous cells is crucial for successful treatment, hence active research has been focused on developing biomarkers based biosensors. Herein, we report the use of antibody-functionalized AlGaN/GaN high electron mobility transistor (HEMT) for a fast detection of the prominent tumor marker of carbohydrate antigen 19-9 (CA 19-9). The antibody of CA 19-9 was embedded to the sensing gate area of the HEMT device through self-assembled monolayer (SAM) technique. The source-drain current showed a swift response when the target CA 19-9 in a buffer solution at analytic concentrations was added to the antibody-immobilized surface. The lowest detectable concentration was 15 U/mL suitable for clinical detection of pancreatic cancer. Our experimental results clearly demonstrate the possibility of development of a portable HEMT sensor for rapid cancer screening and post-treatment tracking.