Abstract
Fascin overexpression in nasal mucosa in patients with chronic rhinosinusitis with and without nasal polyps
Highlights
Introduction methodsChronic rhinosinusitis (CRS) is an inflammatory disease of nasal and paranasal mucosa that lasts at least twelve weeks[1]
Fascin is an evolutionarily conserved 55kDa protein involved in the formation of bundles from actin microfilaments[13,14,15]
It is used by the cells for microspikes, filopodia, and invadopodia e0622020
Summary
The aim of our research is to assess fascin expression in nasal tissues of patients with chronic rhinosinusitis with (CRSwNP) and without (CRSsNP) nasal polyps. Methods: Fascin expression in nasal tissues of 11 CRSwNP patients and 10 CRSsNP patients was immunohistochemically evaluated and compared with control subjects. Results: Fascin was found to be strongly expressed in epithelial cells in polyps in CRSwNP and nasal tissue in CRSsNP. Resultados: Fascina foi encontrada por ser fortemente expressa em células epiteliais em pólipos na RSCcPN e em tecido nasal na RSCsPN. Objetivo: El objetivo de esta investigación fue evaluar la expresión de fascina en los tejidos nasales de pacientes con rinosinusitis crónica con (RSCcPN) y sin pólipos nasales (RSCsPN). Resultados: Fascina fue encontrada por ser fuertemente expresada en células epiteliales de pólipos en la RSCcPN y en tejido nasal en la RSCsPN. Palabras clave: fascina; pólipos nasales; rinosinusitis crónica; actinas; transición epitelial-mesenquimal
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