Familial urothelial cell carcinoma of the bladder with autosomal dominant inheritance and late onset phenotype.

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ObjectiveFamilial Urothelial cell bladder cancer is rare. We report two families with urothelial cell carcinoma (UCC) of bladder with family history in other relatives, displaying probable autosomal dominant inheritance and a late onset pure UCC phenotype, and document the phenotype in each family.MethodsDescriptive familial study on two pedigrees over three generations.ResultsTwo families with UCC bladder were identified, and the phenotype documented, each family having three cases of late onset UCC.ConclusionSome cases of UCC are hereditary and may display autosomal dominant inheritance with late onset of the cancer. Clinicians should be aware of the existence of a familial late onset UCC phenotype when managing cases of UCC.