Abstract
Familial celiac disease was demonstrated in at least 2 members of a studied family. Intestinal disaccharidase activity, evaluated in 4 members of the family by qualitative and quantitative assays of their intestinal mucosa, was found to be diminished. Disaccharidase activity improved after removal of gluten from the diet but lactase deficiency persisted. The histologic appearance of the intestinal mucosa improved with prolonged therapy; however, lactase deficiency persisted even after the mucosa had returned to normal. Possibly an underlying lactase deficiency precipitated gluten-sensitive enteropathy with mucosal damage and additional disaccharidase deficiencies.
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