Abstract
BackgroundTo explore the familial aggregation and heritability of hypertension in Han in Shanghai China.MethodsAccording to l:l matched pairs design, 342 patients of hypertension and 342 controls were selected and investigate their nuclear family members in the case-control study. The method of genetic epidemiology research was used to explore the familial aggregation and heritability of hypertension.ResultsThe prevalence rate of hypertension of first-degree relatives was significantly higher (34.44%) than that of second- degree relatives (17.60%) and third-degree relatives (13.51%) in Han Population in Shanghai China. Separation ratio p was 0.217, and prevalence rate of case group relatives was higher than that of control group relatives. The results showed a phenomenon of familial aggregation in the distribution of hypertension. The heritability of first- degree relatives was 49.51%; that of second-degree relatives and third-degree relatives were respectively 23.42 and 21.41%.ConclusionThe distribution of essential hypertension has phenomenon of familial aggregation in Han Population in Shanghai China. The separation ratio of essential hypertension in this study shows that essential hypertension conform to the characteristics of multigene genetic disease. The heritability of first-degree relatives is bigger than that of second-degree relatives and third-degree relatives.
Highlights
Essential hypertension is a disease caused by a variety of factors
Some studies suggest that there are two major factors affecting the incidence of hypertension: one is the genetic factor; the other is environmental factors, such as overweight and obesity, smoking, mental stress, lack of physical activity, high salt intake, and excessive drinking, anxiety, irritability and other emotional factors, lead to an increased serum epinephrine and blood pressure [1,2,3,4,5,6,7,8,9,10]; Shortage of sleep has been demonstrated to be associated with elevated blood pressure as well [11]
The genes associated with essential hypertension may be a group and micro effect mode, each of which plays a different role in different stages of the formation and
Summary
Essential hypertension is a disease caused by a variety of factors. Some studies suggest that there are two major factors affecting the incidence of hypertension: one is the genetic factor; the other is environmental factors, such as overweight and obesity, smoking, mental stress, lack of physical activity, high salt intake, and excessive drinking, anxiety, irritability and other emotional factors, lead to an increased serum epinephrine and blood pressure [1,2,3,4,5,6,7,8,9,10]; Shortage of sleep has been demonstrated to be associated with elevated blood pressure as well [11].Essential hypertension (EH) is a complex disease influenced by genetic and environmental factors, in addition to genetic factors, several evidence suggest that stress contributes to the genesis of EH. Essential hypertension is a disease caused by a variety of factors. Some studies suggest that there are two major factors affecting the incidence of hypertension: one is the genetic factor; the other is environmental factors, such as overweight and obesity, smoking, mental stress, lack of physical activity, high salt intake, and excessive drinking, anxiety, irritability and other emotional factors, lead to an increased serum epinephrine and blood pressure [1,2,3,4,5,6,7,8,9,10]; Shortage of sleep has been demonstrated to be associated with elevated blood pressure as well [11]. Essential hypertension (EH) is a complex disease influenced by genetic and environmental factors, in addition to genetic factors, several evidence suggest that stress contributes to the genesis of EH. It is believed that the genetic factor of hypertension is made up of a number of pathogenic genes that have a small but cumulative effect. To explore the familial aggregation and heritability of hypertension in Han in Shanghai China
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