Abstract

To the Editor: Total triiodothyronine (T3)1 (TT3) measurements can provide clinical utility elucidating T3-dominant Graves' disease and other thyrotoxicosis conditions. Thyroid hormone assays, including TT3, are susceptible to protein-based interferences, usually caused by endogenous antibodies. Interferences should be considered when the thyroid hormone concentrations are inconsistent with clinical impression (1). We detected an interference with the Ortho® Vitros TT3 assay causing falsely increased concentrations in 20 pediatric patients, some of whom had a history of high TT3 for years, suggesting that the interference was not limited to a single reagent lot. The erroneous results were questioned …

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