Abstract
SummaryMonophasic action-potentials were recorded in isolated frog sciatic nerves in a humid chamber; constant electric stimuli were given in each experiment at a regular rate of between 12 and 30 stimuli per minute. Preparations were irradiated with 50 kv x-rays delivered at a rate of 67 krad/min and were given doses of between 11 and 23 krad. Sub-maximal action-potentials showed an increase of size within 2 sec of commencement of irradiation, and the increase persisted for at least 15 min after the end of the irradiation. The increase was caused by a fall in threshold of the axons in the nerve trunk. However, irradiation did not affect the size of maximal action-potentials, did not produce any gross change of shape in the action-potentials, and did not allow ephaptic transmission between adjacent axons in the nerve trunk.
Published Version
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