Abstract
Failure of pregnancy in dogs and cats is approached as a diagnostic investigation of an individual animal. It begins with a preliminarydiscussion on zoonotic disease and expectations (seldom is the case) of evaluation. General approach from a pathologypoint of view is to identify potential infectious causes of pregnancy failure and to correlate these observations with lesions. Potentialinfectious agents include eubacteria, fungi, viruses and protists. When infectious causes have been ruled out, the focus isthen on noninfectious causes and particularly those with lesions. Maternal evaluation, including endometrial biopsy after uterineinvolution, is part of the investigation. Special effort should be made to collect umbilical arteries and lungs of fetus, and fetalmembranes around the marginal hematoma. Failure of pregnancy due to noninfectious causes without lesions contributes to alarge percentage of cases, suggesting maternal, paternal, molecular, nutritional, or toxic causes.
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