Abstract
Summary Stimulation by phosphoenolpyruvate (PEP) of Ca 2+ efflux from preloaded rat liver mitochondria is associated with an enhanced respiratory rate and is dependent on the P i concentration of the extramitochondrial medium. PEP-induced Ca 2+ efflux is inhibited by concentrations of NEM, mersalyl, and DTNB that also inhibit the respiration-linked transport of P i as well as by bongkrekic acid at concentrations that also inhibits the adenine nucleotide translocase. Since PEP can gain access to the mitochondrial matrix by means of a carrier mediated exchange with intramitochondrial adenine nucleotides, we conclude that the ability of PEP to induce Ca 2+ efflux could be associated with adenine nucleotide efflux as well as P i influx and that the stability of the accumulated Ca 2+ is likely to be controlled by the intramitochondrial ATP/P i ratio.
Published Version
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