Abstract
A method is described for following the percutaneous absorption process with a vapor-phase chromatography technique. Data showing the absorption of methyl ethyl ketone (MEK) from a forearm surface of 91.5cm.<sup>2</sup> under both normal and hydrous conditions of the stratum corneum are presented. Hydration of the stratum corneum enhanced the percutaneous absorption rate of methyl ethyl ketone, but this penetrant subsequently partially dehydrated the stratum corneum. The resulting steady-state concentration of MEK in expired air, however, was still higher than that obtained with normal skin.
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