Abstract
Research questionWhat factors affect the incidence of mosaic embryos resulting from assisted reproductive technology? DesignA retrospective analysis of data from preimplantation genetic testing for aneuploidies in 544 couples was conducted using data from an electronic medical record database. ResultsOf 1910 embryos studied, 127 (6.6%) were mosaic. In multivariable logistic regression analysis, mosaicism incidence increased in embryos from IVF versus intracytoplasmic sperm injection (ICSI) (odds ratio [OR] 4.560, 95% confidence interval [CI] 2.800–7.424, P < 0.001), and in embryos from abnormal versus normal semen (OR 3.496, 95% CI 2.455–4.979, P < 0.001). Embryos tested using SurePlex 24Sure had lower mosaicism percentages than those tested using MALBAC-NGS and PicoPLEX GenetiSure (OR 2.726, 95% CI 1.532–4.852, P = 0.001; OR 2.389, 95% CI 1.537–3.711, P < 0.001, respectively). ConclusionsSemen quality, fertilization method and detection system are independent factors associated with embryonic mosaicism.
Published Version
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