Abstract
ObjectiveThe aim of our research was to evaluate the relationship involving left ventricular ejection fraction, low density lipoprotein, B-type natriuretic peptide, Troponin I and coronary flow reserve, and to determine the predictors of left ventricular ejection fraction in patients with coronary microvascular disease and obstructive coronary artery disease, and in patients with coronary microvascular disease.ResultsThe mean age was 58.5 ± 12.5 years. In patients with obstructive coronary disease and coronary microvascular disease we found low density lipoprotein-c had significant inverse relationship with left ventricular ejection fraction, left ventricular ejection fraction also had significant negative relationship with B-type natriuretic peptide, and Troponin-I. While a significant direct relationship turned out to be observed linking left ventricular ejection fraction with coronary flow reserve. Left ventricular ejection fraction had significant negative relationship with low density lipoprotein, and B-type natriuretic peptide in patients with obstructive coronary artery disease only. Age, blood pressure, lipid levels, red cell distribution width, glycated hemoglobin, symptoms, New York heart association classification, alcohol drinking, hypertension, diabetes mellitus, troponin levels and B-type natriuretic peptide were the predictors for left ventricular ejection fraction in coronary microvascular disease patients.
Highlights
Coronary artery disease is a major non communicable disease problem around the world
There were no studies done in evaluating the low density lipoprotein, B-type natriuretic peptide, Troponin-I and coronary flow reserve in association with left ventricular ejection fraction in patients with obstructive coronary artery disease and coronary microvascular disease
Study objective The intention of this research was evaluating the relationship between left ventricular ejection fraction and low density lipoprotein, brain natriuretic peptide, Troponin I and coronary flow reserve, and to determine the predictors of left ventricular ejection fraction in patients with coronary microvascular disease and obstructive coronary artery disease
Summary
Coronary artery disease is a major non communicable disease problem around the world. Previous studies were done to investigate serum total cholesterol in relation to left ventricular ejection fraction and coronary artery disease where they found out higher total cholesterol and high density lipoprotein. Mayala et al BMC Res Notes (2020) 13:157 are associated with higher left ventricular ejection fraction [5, 6]. There were no studies done in evaluating the low density lipoprotein, B-type natriuretic peptide, Troponin-I and coronary flow reserve in association with left ventricular ejection fraction in patients with obstructive coronary artery disease and coronary microvascular disease. We used a prospective clinical observational design to investigate the association between left ventricular ejection fraction and low density lipoprotein, B-type natriuretic peptide, Troponin-I, and coronary flow reserve and to determine the predictors of left ventricular ejection fraction
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