Abstract
BACKGROUND: Acute coronary syndrome (ACS) remains major cause of death worldwide, therefore it is important to determine factors associated with worse outcomes to better elucidate which patients deserve a more aggressive approach for management. OBJECTIVES: To describe the characteristics of patients admitted with ACS to Kediri General Hospital and factors associated with in-hospital mortality in ACS patients. METHODS: In this cross-sectional study, 117 patients who admitted with ACS to Kediri General Hospital between January and June 2020 were included. Data were collected retrospectively from medical records and analyzed using SPSS software v25. RESULTS: During hospitalization, 18 (15,4%) died. The bivariate analysis showed the patients who died were predominantly female, had higher prevalence of Killip IV, higher prevalence of clinical signs of heart failure, lower admission systolic and diastolic blood pressure, and higher heart rate. From multivariable analysis, variables which were significantly associated with in-hospital mortality were decreased consciousness (OR 11, 95% CI 1.327-92.4, p=0.026), and Killip class IV (OR 9.558, 95% CI 2.016-45.317). CONCLUSION: Decreased consciousness and Killip class IV were associated with increased inhospital mortality in ACS. KEYWORDS:In-hospital mortality, acute coronary syndrome, Killip class, Decrease of Conciousness
Highlights
Acute coronary syndrome (ACS) continues to be a leading cause of death around the world
Variables significantly associated with in-hospital mortality were decreased consciousness (OR = 11; 95%confidence intervals (CIs) = 1.327-92.4; p = 0.026) and Killip class IV (OR = 9.558; 95%CI = 2.016-45.317; p = 0.004)
Decreased consciousness and Killip class IV were associated with increased in-hospital mortality in ACS
Summary
Acute coronary syndrome (ACS) continues to be a leading cause of death around the world. The incidence of ACS was 141/100,000 people per year in 2006, with a 7% death rate. Considering the high mortality rate, it is necessary to determine factors associated with worse outcomes to elucidate better which patients deserve a more aggressive approach for management. Several established risk scores for quantitative risk stratification, such as GRACE scores, did not systematically include Asian countries, so these scores may underestimate or overestimate actual risk when applied to these countries.[1,2] In this study, we described the characteristics of patients hospitalized with ACS to Kediri General Hospital and factors associated with in-hospital mortality in ACS patients
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