Factors associated with adverse postoperative outcomes in patients with long bone post-traumatic osteomyelitis.

Abstract

To evaluate short-term clinical and functional outcomes following operative treatment of long bone post-traumatic osteomyelitis (PTOM). We retrospectively analyzed a consecutive cohort of 142 adult patients undergoing operative treatment of long bone PTOM at our Level I trauma center over a 10-year study period. In addition to subjective patient evaluations, surveyed postoperative outcomes included incidence of residual infection, fracture malunion or nonunion, and requirement for limb amputation. All included patients had a minimum follow-up of 12months postoperatively. Patients suffering an adverse postoperative outcome tended to have a higher incidence of polymicrobial infection (25.4 vs. 11.4%, p=0.042) and requirement for skin grafting (58.1 vs. 37.9%, p=0.024) and free-flap procedures (43.6 vs. 19.5%, p=0.003) compared to those achieving complete healing. Sequential administration of parenteral and oral antibiotic therapies was associated with a reduced incidence of adverse postoperative outcome (p=0.047). Patients with long bone PTOM and extensive soft tissue defects often fail to develop complete remission of their symptoms by 12months postoperatively. Sequential administration of parenteral and oral antibiotics may help to limit infection recurrence. Further research is required to inform optimal treatment strategy.