Factors affecting the recurrence of primary liver cancer treated by hepatic artery chemotherapy combined with radiofrequency ablation

Abstract

Objective To analyze the factors affecting recurrence of primary liver cancer treated by hepatic artery chemoembolization combined with radiofrequency ablation. Methods A total of 85 patients with primary liver cancer treated by chemotherapy embolization combined with radiofrequency ablation in the Fourth People’s Hospital of Datong from January 2013 to January 2017 were selected as research objects. All patients were followed up for 3, 6, 12 and 24 months after treatment. The recurrence rate of tumor was recorded, and the influencing factors of tumor recurrence were analyzed. Results The recurrence rate was 8.24% at 3 months, 11.76% at 6 months, 15.29% at 12 months and 23.53% at 24 months. Univariate analysis showed that there was no statistically significant difference in the gender and age of patients with recurrence and those without recurrence (P>0.05). There were statistically significant differences in tumor major diameter, Child-Pugh grade, tumor number, vascular invasion and tumor, node and metastasis (TNM) stage between patients with recurrence and those without recurrence (P 1, P<0.05). Conclusions Hepatic arterial chemotherapy combined with radiofrequency ablation in treatment of primary liver cancer can significantly lower recurrence rate. Tumor major diameter more than 6 cm, Child-Pugh grade of B, tumor number more than 2, vascular invasion, TNM stage for Ⅲ - Ⅳ are the risk factors of postoperative recurrence. Key words: Primary liver cancer; Chemoembolization of hepatic artery; Radiofrequency ablation