Factors Affecting the Difference in Refractive Error According to Pupil Size in Myopia

Abstract

Purpose : In this study, we investigated the factors that influence the difference in refractive error according to pupil size. Methods : The subjects were 75 eyes(75 adults) of 18 to 58 years of age with myopia and no history of eye disease or surgery except cataract and a best-corrected visual acuity(BCVA) of 1.0 or higher. The i.profilerplus(Zeiss, Germany) was used to obtain the manifest refraction(MR) and corneal and ocular aberration in the 5 mm and 3 mm area of the pupil in the half dark room(5~50 lx). To compare the measured values according to pupil size paired t-test was used. The Spearman correlation test was used to examine the correlation between the difference in spherical equivalent(SE) depending on pupil size and high order aberration. Multiple regression analysis was performed to evaluate the factors affecting the difference in refractive error according to pupil size Results : The mean SE were –4.08±2.90 D and -3.84±2.95 D at 5 mm and 3 mm, respectively (p<0.001). There was a negative correlation between the difference in SE depending on pupil size and ocular higher-order aberration (r=-0.676, p<0.001). After adjusting age and sex, spherical aberration(Z40) and vertical astigmatism(Z4-2) were found to affect the difference in SE depending on pupil size. Conclusion : The interaction of low and high aberrations can cause the differences in mean SE. Therefore, in order to increase satisfaction when wearing glasses, the spectacles prescription considering the high order aberration should be calculated.