Abstract
The transglutaminase Factor XIII (FXIII) generates fibrinolytic-resistant blood clots by crosslinking reactive glutamines and lysines between fibrin and other proteins. The fibrin(ogen) αC region (233-425) encompasses three reactive glutamines (Q237, Q328, and Q366) and a FXIII binding site (αC 389 – 403). αC E396 was reported to be instrumental for FXIII binding, but its absence diminishes but does not prevent crosslinking. This project seeks to identify additional residues within Fbg αC 389 – 403 that accelerate transglutaminase activity toward αC based on interactions with complementary residues in FXIII.
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