Factor-V-Leiden Mutation in A Neonate Presenting With Arterial Ischemia

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Factor V Leiden mutationis a rare cause of familial thrombophilia, more commonly seen in Caucasians. It is associated with thromboembolism in the neonatal population [1]. We report a case of a term female infant who developed an arterial ischaemicright thumb and the dorsum of the right hand several hours after birth and as part of the work up the babywas found to have Factor V Leiden Mutation (Heterozygous). Parents who are of Middle Eastern origin hadno family history of thrombophilia. The baby was born in good condition and the only significant perinatal history was gestational diabetes which is another known risk factor for neonatal thromboembolism. The neonate was successfully managed with subcutaneous low molecular weight heparin and hyperbaric topical oxygen. We think the presence of factor V Leiden associated with gestational diabetes predisposed to this rare presentation.