Abstract
Zhou, A.-W., W.-X. Li, J. Guo and Y.-C. Du. Facilitation of AVP(4–8) on gene expression of BDNF and NGF in rat brain. Peptides 18(8) 1179–1187, 1997.—In situ hybridization and Northern blot assay were used to evaluate the effects of exogenous AVP(4–8) on the transcription of mRNAs for nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT-3) in the adult rat brain. NGF and BDNF expression was found to be significantly enhanced by AVP(4–8) administration in the cerebral cortex and hippocampus, but NT-3 expression was not changed. In the same conditions, behavior-active arginine-vasopressin (AVP) showed a small effect and its behavior-inactive homologue, oxytocin did not. Our results suggest that selective regulation of neurotrophin gene expression by the peptides may be responsible for its memory-enhancing function.
Published Version
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