Facile synthesis of Cu-BDC MOF via solvothermal method for biosensor application

Abstract

Combining the merit of metal and organic substance, Metal Organic Frameworks (MOFs) have been considered as a promising biosensor material. By the nature characteristic of MOFs themselves and/or the modification with other materials, allowing MOFs to be applied for various of biological substance/organism, e.g. protein, DNA, RNA, bacteria, and even virus. In this work, we investigated the potential of copper-based MOF (Cu-BDC) as a non-enzymatic biosensor, specifically for dopamine (DA) detection. The detection of DA concentration level is immensely important in monitoring the health of our nervous system and in diagnosing a neurodegenerative disorder, e.g. Parkinson disease. In our work, we presented a facile synthesis of Cu-BDC MOF biosensor using sonochemical method with ultrasonication pre-treatment for the detection of DA at various concentration level. The SEM image of the synthesized Cu-BDC showed that it has a homogeneous particle size distribution of 300 nm. Drop casting it onto glassy carbon electrode (GCE), altering it to serve as an electrochemical based biosensor. From electrochemical measurement, the Cu-BDC modified electrode exhibited an excellent electron transfer and electrocatalytic activity with a low oxidation potential (0.32V) of DA detection. Furthermore, the electrode biosensor was then evaluated in detecting various DA concentration level. The result showed that it has a wide linear detection range of 100 µM -1000 µM with a limit of detection (LOD) of 44.5 µM. All these results demonstrated our successful and outstanding facile synthesis method of Cu-BDC MOF as a sensitive biosensor.