Facile Synthesis, Characterization, and In Vitro Antimicrobial and Anticancer Activities of Biscoumarin Copolyester Bearing Pendant 3-(Trifluoromethyl)Styrene.

Narendran Kandaswamy,Nanthini Raveendiran

doi:10.1155/2014/369473

Abstract

Synthesis of random biscoumarin copolyester bearing pendant 3-(trifluoromethyl)styrene was prepared by the reaction of biscoumarin monomer 3 and hydroquinone 5 with azeloyl chloride. The influence of pendant 3-(trifluoromethyl)styrene unit on the properties of copolyester such as inherent viscosity, solubility, and thermal stability was investigated and compared in detail. The inherent viscosity and polydispersity index of the copolyester were found to be 0.15 dL/g and 1.36, respectively. The chemical structure of the copolyester was investigated by Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (1H-NMR) spectroscopy. The physical properties of copolyester were characterized by thermogravimetric analysis (TGA), differential scanning calorimetry (DSC), gel permeation chromatography (GPC), and X-ray diffraction (XRD) technique. Agar disc diffusion method was employed to study the antimicrobial activity of the random copolyester. In vitro anticancer activity against lung cancer (Hep-2) cell line was also investigated.

Highlights

Aliphatic aromatic copolyester [1,2,3] bears high thermal stability and excellent mechanical strength and is being used in various disciplines
Antibacterial activity of random copolyester was determined by disc diffusion method on Muller Hinton agar (MHA) medium and Sabouraud Dextrose agar (SDA) medium, respectively
The polymer exhibited characteristic absorption bands at 1726 cm−1; this is attributed to the presence of carbonyl stretching of ester group. Both monomer and polymer exhibited peak at 1648 cm−1; this is due to the stretching of carbonyl group of biscoumarin unit

Summary

Introduction

Aliphatic aromatic copolyester [1,2,3] bears high thermal stability and excellent mechanical strength and is being used in various disciplines. In spite of unique properties such as thermal stability, good chemical resistance, and excellent mechanical strength, these polymers encounter the problem of fabrication process due to high glass transition temperature and poor solubility in common organic solvents. Implantation of surgical devices like sutures, prosthesis anchor, staples, and valves may lead to incorporation of foreign object into the human body that has the potential to infect patients with various microbes. The aim of the present investigation is to synthesize and characterize a random copolyester containing biological active biscoumarin group bearing 3-(trifluoromethyl)styrene by inherent viscosity measurements, solubility tests, FTIR, 1H-NMR spectroscopy, X-ray diffraction analysis (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC). The synthesized copolyester was subjected to in vitro anticancer activity against lung cancer (Hep2) cell line and antimicrobial studies

Experimental

Results and Discussion

Conclusion