Abstract
AbstractIn this study, the Zn nanoparticles were synthesized using the peel extract of Citrus aurantium. The nanoparticles were characterized by different chemical techniques including UV‐Vis. and FT‐IR spectroscopy, and SEM technique. The results revealed a spherical shape with an average size of 41.17 nm was identified for the green‐synthesized nanoparticles. In the antioxidant test, the IC50 of nanoparticles and butylated hydroxytoluene (BHT) against DPPH free radicals were 115 and 96 μg/mL, respectively. In the cellular and molecular part of the recent study, the treated cells with nanoparticles were assessed by the MTT assay for 48 h about the cytotoxicity and anti‐human bone cancer properties on normal (HUVEC) and cancer cell lines, that is, A‐673 and HS‐729. The IC50 of nanoparticles were 278 and 256 μg/mL against A‐673 and HS‐729 cell lines, respectively. The viability of malignant cell lines reduced dose‐dependently in the presence of Zn nanoparticles. It seems that the anti‐cancer effect of recent nanoparticles is due to their anti‐oxidant effects. After evaluating the effectiveness of this formulation in clinical trial researches, it can be a good alternative to chemotherapy drugs.
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