Facile one-pot synthesis and drug storage/release properties of hollow micro/mesoporous organosilica nanospheres

Abstract

Novel hollow micro/mesoporous organosilica nanospheres (HMOSNs) of uniform diameter and shell thickness of about 90 nm and 15 nm, respectively, and with wormlike micro/mesoporous shell full of uramido groups, have been successfully fabricated by a facile one-pot route. The micro/mesoporosity of the synthesized HMOSNs has been characterized by small-angle and wide-angle X-ray diffraction (XRD), scan electron microscopy (SEM), transmission electron microscopy (TEM) and nitrogen adsorption–desorption measurements. The drug storage and release properties of the synthetic HMOSNs are measured by using ibuprofen (IBU) as a model drug, and a high drug storage capacity of 531 mg IBU per gram HMOSNs and a steady drug release behavior are exhibited.