Facile one‐pot three‐component route to an assembly of 2‐amino‐4H‐chromenes and spirochromenes promoted via ceria nanoparticles in a benign manner

Abstract

AbstractIn this study, a series of 2‐amino‐4H‐chromenes and spirochromenes were elaborated and synthesized via a new sustainable one‐pot three‐component strategy from easily available materials including phloroglucinol, malononitrile, and aldehydes/isatins. Ceria nanoparticles (CeO2 NPs) were successfully applied as an effective catalyst that recycled and reused with a marginal decrement in its catalytic performance. The Lewis acid–base nature of the described nanocatalyst afforded the high yields of target products. The reaction is run in ethanol as a green solvent to create an environment‐friendly process. The other salient merits of this methodology are a broad substrate scope, a simple operation, shorter reaction times, and no need for column chromatographic purification.