Abstract
A three-component one-pot synthesis was performed to obtain 4-amidoaralkyl-3-hydroxyquinolines (4a-j), belonging to heterocyclic class of compounds. These derivatives were obtained by the fusion of 3- hydroxyquinoline (1), aromatic aldehydes (2a-j) and amides (3a-j) in the presence of ZnO nanoparticles under solvent free conditions at 40oC temperature. Using 1HNMR, 13CNMR, FTIR spectral techniques and LC-MS analytical technique, the structural and elemental aspects of the derivatives have been confirmed. Higher yields and less reaction time (1.5 h) were the major outcomes of the protocol and further, greater recoverability of ZnO NPs was observed. The anti-bacterial activity of the quinoline derivatives (1st cycle) has been evaluated against Staphylococcus aureus and Escherichia coli organisms. Anti-diabetic activity was also tested against insulin as the standard. It was found that the majority of the derivatives (4a-j) possessed greater biological activities in both the performed investigations.
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