Abstract
In view of biopolymer's importance in the drug delivery area, this study aimed to investigate the potential of a new drug carrier based on methotrexate-loaded layered double hydroxide (ZnAl-LDH/MTX) and carboxymethyl starch (CMS) as a specific intestinal delivery vehicle. Briefly, the ZnAl-LDH was first synthesized via a facile co-precipitation process and then the MTX was loaded on it. MTX loading capacity of ZnAl-LDH was calculated up to ∼23.7%. FT-IR, UV–Vis, and XRD analysis confirmed the successful formation of ZnAl-LDH/MTX. ZnAl-LDH/MTX released about 100% of the loaded MTX in the initial 2 h in simulated stomach media. To overcome this challenge the ZnAl-LDH/MTX was coated with CMS (CMS@ZnAl-LDH/MTX). The CMS@ZnAl-LDH/MTX displayed limited drug releases at pH 1.2 and a higher percentage of the drug was released at pH 6.8 and 7.4; owing to the pH-responsive nature of CMS. The CMS@ZnAl-LDH exhibited good biocompatibility, but CMS@ZnAl-LDH/MTX was toxic toward the studied cell line. In comparison to the pristine LDHs based drug carriers, the controlled and sustained drug delivery of CMS@ZnAl-LDH/MTX could be a valuable advantage for it, so, the results strongly suggest the potential of CMS@ZnAl-LDH/MTX with biodegradable nature for controlled drug delivery to the lower gastrointestinal tract.
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