Abstract
The healing of diabetic wounds is a difficult problem due to decreased proliferation, and migration of epidermal and endothelial cells. Here we reported semaglutide-loaded nanofiber membrane to promote diabetic wound healing through suppressing reactive oxygen species production and accelerating angiogenesis in a diabetic rat model. The fiber membrane was prepared by an electrostatic spinning technique. The fiber membrane consisted of thermalplastic polyurethane elastomer, polyvinyl butyral ester, zein and semaglutide (SMGT). The fiber membrane had a uniformly distributed diameter, suitable water vapor transmission rate, good water absorption and retention properties. In vivo data determined that the SMGT-loaded nanofiber membrane was able to promote normal skin pathological structure formation in regenerated tissue. In vitro experiments displayed that SMGT might facilitate HG-induced endothelial cell dysfunction by inhibiting ROS production. The present study provided a theoretical basis for the extensive application of SMGT in the treatment of diabetic ulcers and other wounds.
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