Facial preparation of trifluoroacetic acid-immobilized amino-functionalized silica magnetite nano-catalysts as a highly efficient and reusable for synthesis of β-enaminones

Abstract

In this paper, a simple method is reported for the preparation of trifluoroacetic acid immobilized silica magnetite nanoparticles. It is a new magnetic nano-catalyst for β-enaminone synthesis from 1 3-dicarbonyl compound. The magnetic nano-catalyst preparation was successfully synthesized by two different methods based on continuous flow synthesis. The synthesized magnetic nano-catalysts were identified using Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), energy diffusion scanning electron microscopy (SEM-EDX). N2 adsorption isotherm, thermal gravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), and vibrating sample magnetometry (VSM) to confirm chemical composition, morphology, thermal stability, and magnetization. The magnetic nano-catalyst was found active the synthesis of β-enaminones. The magnetically nano-catalytic system employs environmentally friendly, solvent-free mild reaction conditions, various β-enaminone products requiring good to excellent yield under mild reaction conditions. This β-enaminone synthesis protocol has several advantages in terms of introducing a novel magnetically nano-catalytic system based on the recovery capability of the magnetic nano-catalyst. The reusability of the magnetic nano-catalyst was also studied for 7–8 consecutive cycles without significant loss of catalytic activity.