Fabrication and in vitro evaluation of Ca11B2Si4O22 ceramic for bone tissue engineering

Abstract

• For the first time, a novel Ca 11 B 2 Si 4 O 22 powder was prepared by a sol-gel method. • In vitro experimental results indicated that the Ca 11 B 2 Si 4 O 22 ceramic enhanced osteogenic differentiation of mBMSCs. • Ca 11 B 2 Si 4 O 22 ceramics had good mechanical property. Calcium borosilicates are bioactive materials. This work synthesized a novel Ca 11 B 2 Si 4 O 22 powder by a sol-gel method. Besides, Ca 11 B 2 Si 4 O 22 ceramic was prepared via the dry-pressure molding and high temperature sintering. XRD analysis results revealed that the high-purity Ca 11 B 2 Si 4 O 22 crystalline powder was successfully prepared. Meanwhile, the compressive strength of the Ca 11 B 2 Si 4 O 22 ceramic reached to 290 MPa. More interestingly, the Ca 11 B 2 Si 4 O 22 ceramic exhibited excellent apatite-forming ability in simulated body fluid and osteogenic activity in vitro . These results indicated that the novel Ca 11 B 2 Si 4 O 22 ceramic holds great potential for load-bearing bone repair.