Abstract
Recently, a novel dosage form topical vaginal delivery has been developed utilizing drug-fibers fabricated by electrospinning. Biocompatible and biodegradable nanofiber meshes suitable for drug delivery systems were electrospun based on poly (ethylene oxide) (PEO) with high molecular weight (HMW) and low molecular weight (LMW) to design innovative vaginal delivery systems. It is desirable to encapsulate a drug inside the fibers to enhance the drug antiviral activity in addition to controlling the fiber diameter. The surface morphology and average diameter of the nanofibers were determined by field emission scanning electron microscopy (FE-SEM). Based on SEM results it was revealed that the HMW PEO has more uniform nanofibers with good average diameters than LMW PEO. We formulated acyclovir (ACV) at 20 wt% into electrospun solid dispersions construct from PEO nanofibers and examined distribution in characterizing drug release rates into aqueous media. We assumed that ACV-loaded PEO nanofiber scaffolds were prepared using electrospinning when applied to vaginal environment, should remain undamaged as long as the environment is acidic.
Published Version
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