Abstract
Gold-patterned glass substrates sealed to a PDMS fluidic layer is an architecture widely employed in microfluidic devices. The plasma bonding method is commonly used but presents the disadvantage of being ineffective on gold surfaces, creating a sealing weakness where solution leakage can be a problem. Frequently, alternative approaches to sealing include additional patterned layers that often require expensive cleanroom time. Here we demonstrate a sealing method involving carboxyl-terminated and amine-terminated silanes appropriate for PDMS-based device fabrication with patterned gold/glass surfaces. This cleanroom-free methodology improves solution leak pressure 37-fold compared to the standard plasma bonding technique on these patterned substrates. This bonding strategy is demonstrated in a proof-of-concept electrochemical cell enclosed in a PDMS chamber. An electrochemical method for preparing a clean and electroanalytically useful gold surface in the PDMS device is detailed.
Published Version
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