Abstract
The poly(I:C) model is one of the most widely used model of maternal immune activation (MIA). While it is known that the effects of MIA can be influenced by various factors, it has been largely ignored so far, whether differences in housing can also affect the outcomes in the offspring. Here, we examined this possibility by comparing poly(I:C)-based MIA in two housing systems, namely individually ventilated cages (IVC) and open cages (OC).
Highlights
Rodent models of maternal immune activation (MIA) are increasingly used as experimental tools to study neuronal and behavioral dysfunctions in relation to infection-mediated neurodevelopmental disorders such as schizophrenia and autism
Neurodevelopmental mechanisms underlying the winter-like gestation likely contribute to experiential- but not expressive-related behaviors, while altered NMDA receptor function are unlikely to contribute to such experiential-related abnormalities
We examined this possibility by comparing poly(I:C)-based MIA in two housing systems that are commonly used in preclinical rodent research, namely the individually ventilated cage (IVC) and open cage (OC) systems
Summary
Winter-like photoperiod births in mice induced psychiatryrelevant amotivation as measured by breakpoint, though did not affect social interaction or recognition. Subchronic PCP treatment increased breakpoint in rats tested 1 and 7 days after treatment. Neurodevelopmental mechanisms underlying the winter-like gestation likely contribute to experiential- but not expressive-related behaviors, while altered NMDA receptor function are unlikely to contribute to such experiential-related abnormalities. Ongoing work will characterize epigenetic, synaptic, and/or system-level adaptations underlying developmental differences between NA and SA photoperiod born mice as well as defining critical periods throughout gestation and rearing that are driving these effects
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