Abstract

Bone loss and incidence in osteoporotic fractures accelerate after menopause, probably due to loss of positive effects from estrogens on the bone remodelling system. Since the incidence in distal forearm fractures increases already shortly after menopause, before evident boneloss can be visualized, estrogen withdrawal may be speculated to induce balance-problems, increasing the risk for fractures. The objective was to establish whether hormone replacement therapy affects postural balance in postmenopausal women. Nineteen healthy postmenopausal women with vasomotor symptoms were included. They underwent dynamic posturography before and after 4 and 12 weeks of transdermal estrogen treatment (17Restradiol 50ug/day) as well as after two additional weeks of combined estrogen/progestagen treatment. Numerous previous studies with the same method at our and other laboratories have failed to show that the test-retest factor affects outcome. Hormone replacement therapy significantly increased static balance performance assessed by dynamic posturography.

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