F1 Hybrid Antiparental Cell-mediated Lympholysis: A Comparison with Bone Marrow Graft Rejection and with Cell-mediated Lympholysis to Alloantigens

Abstract

According to the classical laws of immunogenetics, immune reactions are not elicited by F1 hybrid immunocytes against parental antigens because of the codominant inheritance patterns of the histocompatibility cell-surface antigens. It has been known for some time, however, that grafts of normal and neoplastic murine hemopoietic cells fail to grow, or proliferate deficiently, under certain conditions in irradiated mice, including F1 recipients of parental bone marrow (Cudkowicz and Stimpfling 1964, 1965; Cudkowicz and Bennett 1971a,b; Cudkowicz and Lotzová 1973; Kitamura et al. 1973; Raushwerger et al. 1973; Lotzová and Cudkowicz 1974; Cudkowicz 1975). In vivo, such resistance has been shown to be mediated by an unusual kind of host antigraft reaction which: (1) is immunogenetically specific; (2) matures during the fourth or fifth week of life; (3) is independent of the thymus (athymic nude mice are strongly resistant); (4) requires the integrity of host bone marrow; (5) is abrogated by...