Abstract
The purpose of this study is to report eyelid myokymia in patients recently recovered from COVID-19 disease. A cohort of 15 patients who developed eyelid myokymia during or immediate post-recovery of systemic disease were evaluated. Demographic, clinical characteristics, effect of age, and hospitalization on the disease course were studied. The disease course was evaluated every month for 3 months period. All, except 2, patients had complete resolution of lid myokymia within 3 months of onset. Median [IQR] myokymia recovery time was 42 [31,60] days. Age and duration of hospitalization had a significant linear relationship with myokymia recovery time. Recovery was delayed by 2.64 days with every 1-year increment in age and by 6.19 days with every additional day of hospital stay. Recovery time was independent of severity of systemic disease (P = .055) and gender (P = 0.2). Eyelid myokymia can be a possible manifestation of COVID-19 recovery phase. While myokymia recovers gradually in all these patients, older age and a longer duration of hospitalization are associated with slower recovery.
Highlights
Coronavirus disease 2019 (COVID-19) is the spectrum of clinical manifestations caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Inclusion criteria were (1) new-onset eyelid twitching noticed by patients during or immediately after COVID-19 infection, (2) age between 18 and 70 years, (3) history of recent COVID-19 infection confirmed with real-time (RT) polymerase chain reaction (PCR) for SARSCoV-2, (4) complete recovery from active systemic infection documented by treating physician using RT PCR test negative for SARS-CoV-2 not earlier than 1 month
Five (33.3%) patients had a history of conjunctivitis during active systemic disease
Summary
Coronavirus disease 2019 (COVID-19) is the spectrum of clinical manifestations caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 is a member of Coronaviridae family [1]. The rapid transmission of the virus has caused a global pandemic with 91.8 million cases and 1.97 million deaths globally [2]. While respiratory disease caused by this virus has been most emphasized, the virus may affect other body systems and functions. Several investigators have described ocular manifestations of SARS-CoV-2. While ocular surface diseases are the most common ophthalmic manifestation of this virus, retinal vascular changes, neuro-ophthalmological complication, and uveal inflammation has been seen in a small number of patients [3,4,5]
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