Abstract
Extraskeletal Osteosarcoma Arising Within A Primary Atrial Myxoma
Highlights
Cardiac tissues have one of the highest concentrations of environmental carcinogen-induced DNA adducts of all tissues [1], the heart is one of the rarest sites of both benign and malignant neoplastic transformation [2]
Nearly 20% of all cardiac neoplasms are malignant with the majority of these consisting of sarcomas [3], these numbers must not belie the rareness of cardiac neoplasms in general
Hemangiosarcomas or angiosarcomas are the most common cardiac sarcoma which predominately arise within the right atrium, extraskeletal osteosarcomas usually arise with the left atrium (LA) [36]
Summary
Cardiac tissues have one of the highest concentrations of environmental carcinogen-induced DNA adducts of all tissues [1], the heart is one of the rarest sites of both benign and malignant neoplastic transformation [2]. Extraskeletal cardiac osteosarcomas have been reported previously as single isolated case reports, the vast majority of which exhibited very poor survival [8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. We report another case of extraskeletal osteosarcoma but one which uniquely arose within a preexisting atrial myxoma and one which has exhibited both prolonged disease-free and overall survival and probable cure
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