Abstract
Extracts of 32 medicinal plants commonly used in Mexico were evaluated for their effects on the growth of Vibrio cholerae strains O1 and O139. Of these, the ethanolic extracts of Acacia farnesiana and Artemisia ludoviciana effectively inhibited bacterial growth. The effects of these plant extracts on enterotoxin production and adhesion of V. cholerae to Chinese hamster ovary (CHO) cells were determined. The minimal bactericidal concentration (MBC) for growth was 4.0–7.0 mg/ml for A. farnesiana and 4.0–6.0 mg/ml in A. ludoviciana spp. mexicana. Cholera toxin was inhibited when lower concentrations (50% or 75% of the MBC) of extracts were added to the media. Pre-exposing bacteria or CHO cells to various concentrations of extracts affected in a different manner the adhesion between bacteria and CHO cells.
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