EXTRACTION AND PHYSICOCHEMICAL CHARACTERIZATION OF NOVEL POTENT MUCOADHESIVE BIO-MATERIAL OBTAINED FROM THE FRESH FRUITS PULP OF ACHRAS ZAPOTILLA

Abstract

Objectives: The objective of present investigation was to isolate an effective novel mucoadhesive biomaterial from the pulp of Achras zapotilla, belonging to Sapotaceae family. In the recent years the research in the biomaterial isolation and their use as pharmaceutical excipients become a core area for formulation scientist to develop safe and effective drug delivery system. Methods: The biomaterial was isolated by simplified economical method and was subjected to phytochemical, physicochemical, micromeritic as well as spectral analyses like IR, 1HNMR, DSC, SEM and Elemental analysis. The mucoadhesive property of the biomaterial was assessed by shear stress method, falling sphere method and rotating cylinder method using nasal mucosa as substrates. Results: The results were compared with HPMC and sodium CMC as a standard. The formation of hydrogen bond by natural mucoadhesive agent with mucosa was confirmed by FTIR spectra showing carboxyl and hydroxyl groups. Conclusion: The research study revealed that the biomaterial obtained from fruit pulp of Acarus zapotila exhibited a promising potent natural mucoadhesive property and may be used to develop mucoadhesive transmucosal drug delivery systems. Peer Review History: Received 4 December 2018; Revised 8 January; Accepted 12 January, Available online 15 January 2018 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 4.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewer(s) detail: Dr. Areen Alshweiat, University of Szeged, Hungary, areen.alshweiat@hu.edu.jo Dr. Emmanuel O. Olorunsola, Department of Pharmaceutics & Pharmaceutical Technology, University of Uyo, Nigeria, olorunsolaeo@yahoo.com Similar Articles: ABACAVIR LOADED NANOPARTICLES: PREPARATION, PHYSICOCHEMICAL CHARACTERIZATION AND IN VITRO EVALUATION